The chances of successful pregnancy with in vitro fertilization is directly related to the age of the woman who provides the egg. Most in vitro fertilization programs divide up their success rates according to age. For example, clinics will report pregnancy rates for women under and over the age of 35 years. There is certainly a deterioration in the quality of eggs from the mid-thirties onwards. Some clinics divide up success rates further, and specifically report pregnancy rates for women between the ages of 35 and 37, 38 and 39, 39 to 42, and then over the age of 42.Our pregnancy rates in year 2011 for women under the age of 35 was 70 %, with a fall-off in pregnancy rates for women between the ages of 36 and 44 years.
Success rates are further influenced by the number and quality of eggs that are retrieved from the ovary, by the quality of the uterus, including the endometrial lining and the presence or absence of uterine fibroids, by the number of embryos that are transferred and also by maternal weight.
Obviously, there are patients in all categories who may have poorer chances of pregnancy success than others of equivalent age. Such patients would include those with a history of previous in vitro fertilization failures, as well as those with limited ovarian reserve and other pelvic factors such as uterine fibroids and tubal disease or endometriosis. This is why it is so difficult to draw conclusions from statistics provided by various clinics. There are indeed some clinics who will not take on women who are obviously at low risk for for successful pregnancy – for fear that a lack of success could adversely skew statistics.
The risks may be divided into various categories:
One of the commonest serious side effects from using fertility drugs is a condition known as ovarian hyperstimulation syndrome (OHSS). Ovarian hyperstimulation syndrome becomes a risk in women who develop more than 20 follicles in response to the fertility drugs. In these circumstances the blood estrogen levels are often very high, and this combination causes OHSS. It is not a very well understood condition, however, this combination of events tends to lead to a metabolic imbalance which increases the risk of thrombosis, as well as having an effect on body tissue permeability, which results in collection of fluids in the abdomen and chest. The best form of management is prevention. Women at particularly increased risk for this condition are women with a condition known as polycystic ovarian syndrome, or younger women with a history of infrequent or longer than average menstrual cycles.
- The risks related to ovulation induction (the use of fertility drugs).
- The risks related to the surgical retrieval of eggs.
- The subsequent risk of pregnancy – specifically of multiple pregnancy.
There are now ways to avoid OHSS. Perhaps the most siginificant advance in ART (Assisted Reproductive technologies) in the past 5 years is the introduction of a new method of freezing called Vitrification. Vitrification allows us to successfully and reliably freeze embryos and eggs. Avoiding a pregnancy in a woman at high risk for OHSS is paramount - this allows the body to recover. It is the pregnancy hormone HCG that aggravates OHSS.
During egg retrieval, a needle is passed under ultrasound guidance through the vagina into the ovaries. The follicles are then aspirated, the fluid collected and the eggs isolated. We use a combination of local anesthetic and intravenous sedation during the procedure. Like any surgical procedure there are risks of bleeding, infection, and injury to structures around the ovary. Such structures include bowel, the ureters and bladder. Prophylactic antibiotics are always used, and the risk of infection, bleeding and organ injury is, in fact, very low.
The main pregnancy risks related specifically to in vitro fertilization are those associated with multiple pregnancies. Our motto is “As Many Babies As You Want, Though Preferably One At A Time”. However, we have a responsibility to maximize chances of pregnancy, keeping in mind a desire to keep the risk of multiple pregnancy to a minimum. As a rule of thumb, we at Victoria Fertility Centre will not transfer more than two embryos in a woman under the age of 35. The number of embryos transferred in women over the age of 35 is largely dependent on their prior IVF history and the quality of the embryos themselves. Just about every pregnancy complication imaginable is increased when there is a multiple pregnancy. The most specific baby-oriented risk of multiple pregnancy is premature delivery. Although twins are somewhat acceptable they are not desired. In higher order multiple pregnancies than twins, a preferred option would be a process called selective reduction, which is done at around 12 weeks’ gestation. This involves sacrificing one of the fetuses to give the others a better chance at reaching maturity.
We are doing our best to now avoid multiple pregnancies. In women with good quality embryos we encourage single emrbyo transfers. Vitrification gives us reassurance that the excess embryos can be safely frozen and used at a later time.
This is an invasive process and certainly involves some discomfort. We give our pateints a cocktail of Ativan,Tylenol and Gravol 30 - 60 minutes before the egg retreival. In the operating room, a combination of a sedative and narcotic is then administered intravenously. The retrieval is then done under ultrasound guidance, and extra narcotic and sedation given as necessary. Most patients find that the procedure is not nearly as uncomfortable as they imagined. If one has to consider the discomforts caused by pregnancy itself, not to mention the labour and delivery process, egg retrieval is normally minor in comparison.
The fertility drugs used do not seem to cause direct side effects, and the side effects are therefore related to the actual effects that these drugs have on the ovaries. As the ovaries begin to swell, there can be some pelvic and abdominal bloating. Some women do experience minor mood changes, headaches and nausea – although all of these are uncommon.
Is there an increased risk of birth defects and chromosome abnormalities in babies born after in vitro fertilization and ICSI?
The risk of any baby being born having a birth defect is between 4 - 6 %
This risk is higher in couples who have a problem conceiving - whether they get pregnant on their own or with feritlity treatments.
There does not seem to be an increased risk of birth defects with standard IVF - however there does appear to be an increased risk of birth and genetic defects in babies conceived with ICSI. This risk appears to be in the region of 8 - 9 %
Any medications we use in medicine for whatever reason may effect the long term risk of cancer. As do social habits and lifestyle. ( eg alcohol, smoking,diet, exercise or lack of it, obesity etc) There are so many variables when it comes to estimating cancer risk.
Any hormonal medications (such as the birth control pill, fertility drugs, hormone therapy after menopause) may influence the incidence of breast and ovarian cancer.
At this time there is some evidence to suggest that women who do IVF before the age of 24 years MAY be at a higher risk to get breast cancer. As far as ovarian cancer is concerned - we just don't know the answer
Does endometriosis affect fertility and can it affect the success rates with in vitro fertilization?
Endometriosis is a condition in which the endometrial cells which normally line the inside of the uterine cavity (womb) grow outside the uterus. Endometriosis usually results in deposits (growths) of endometrial cells, which occur in clusters, typically on the ovaries, fallopian tubes, bladder, pelvic side walls and bowel. Endometriosis can also cause ovarian cysts (called chocolate cysts). Less commonly, endometriosis can occur in other parts of the body such as the lungs, liver and kidneys.
It is a confusing disease which may affect one in ten women during their childbearing years. It is especially common, however, in women having difficulty conceiving, and also in women experiencing pelvic pain. The typical symptoms of endometriosis include painful periods, premenstrual spotting, painful intercourse and difficulty conceiving. Endometriosis should be suspected in any woman with such symptoms. Although a clinical examination and pelvic ultrasound may be completely normal, some clues would include clinical tenderness between the uterus and the rectum felt during an examination, or ovarian cysts identified by ultrasound. The condition can be confirmed by doing a surgical procedure called a laparoscopy. Laparoscopy involves a general anesthetic and passing a small telescope through the belly-button (umbilicus) into the pelvic cavity to allow direct visualization.
Endometriosis may effect fertility in a vaariety of ways.
It may negatively effect egg and embryo quality
It may effect implantation by having a harmful effect on the endometrium and also on the immune system.
It may increase the risk of miscarriage.
Options to treat some of these possibilities will be discussed with you.
There does not seem to be a significant difference in the miscarriage rates conceived naturally or through in vitro fertilization. The single most significant factor related to miscarriage is maternal age. The risk increases with advancing age. For a woman in the early twenties the miscarriage risk is approximately 12%, however, for a woman in her early forties the miscarriage rate is between 40 and 50 %. Other factors that may effect miscarriage rates are weight, fibroids, diabetes, the endometrial thickness and uterine septums( to name a few)
Technology for freezing embryos called Vitrification has significantly changed outcomes and expectations for freezing eggs and embryos. With this technology, the chances of embryos surviving the thaw is mostly greater than 95 %. Also - the chances for implantation and pregnancy is as good as (if not better) than doing a fresh embryo transfer
When the egg provider is over the age of 40 years, the chance of success using her own eggs decreases significantly as we approach the age of 43/44. Between the ages of 40 and 42, the chances for successful pregnancy per cycle is around 30% if three embryos are available for transfer. By the age of 43 to 44, the chance of pregnancy falls to about 10 %. There is also a significantly increased risk of miscarriage, approaching 50%- 75% by the time someone is 43 years old.
In vitro fertilization with egg donation is an option for all patients when egg production or embryo quality appears to be a major factor. This is especially relevant for patients over the age of 40 with decreased ovarian reserve.
For women without ovaries or for women with poor ovarian reserve (usually related to age) an option for successful pregnancy would be in vitro fertilization with donor egg. Preferably, such an egg donor should be under the age of 35. During this process, the egg donor undergoes a cycle of in vitro fertilization. Her ovaries are stimulated in the usual fashion as described elsewhere in this website, and then the eggs are retrieved by transvaginal ultrasound. At the same time that this donor is going through an IVF cycle, the recipient is undergoing a different process. This process involves hormonal treatments to prepare the uterus to receive the embryo.
After the eggs are retrieved from the donor, they are fertilized using the recipient’s partner’s sperm (or donor sperm, depending on the circumstances). The donor’s role is then over.
The embryos are then cultured, and then either on Day 3 or Day 5, transferred into the uterus of the recipient.
Canadian Law does not allow the purchase of eggs. For this reason, in Canada, the egg donor is expected to go through the process with purely altruistic intentions. She is allowed, however, to be legally reimbursed for expenses incurred during the process. There can be no financial coercion during the process.
At VFC, we find that most of our egg donors are either relatives or personal friends.
There is more information on this subject in the "InformationSheet" section.
Fibroids are the commonest tumour found in the human body. They are round muscle growths which occur in the wall of the uterus. They are almost always non-cancerous and harmless. They start as small pea-sized lumps but grow steadily during the reproductive years. They may or may not cause symptoms. Some of the common symptoms include heavy, painful periods and pressure on the bladder and rectum. They can also uncommonly cause pain if they undergo rapid change.
Fibroids that grow into the cavity of the uterus (submucous fibroids) can definitely interfere with fertility. Such fibroids should be removed prior to embarking on in vitro fertilization. Fibroids that grow within the wall of the uterus but do not displace or impact on the cavity of the uterus (the endometrial cavity) can potentially also interfere with the chances of conception. This is a very controversial area. Generally speaking, if fibroids are less than 5 centimetres in size and not impacting on the cavity we do not recommend that they be surgically removed. We always have to remember that a surgical procedure carries risk. The surgical removal of fibroids is called a myomectomy. During a myomectomy there is a risk of damage to the uterus – and as such the pros and cons of doing it should be carefully evaluated.
On the other hand, as mentioned above, if fibroids are growing into the cavity of the uterus they do need to be surgically removed. Most of these can be tackled by doing a hysteroscopy. This involves passing a fine telescope through the vagina and cervix, resecting the fibroids and thereby restoring the uterine cavity to normal.
The frustration and sadness caused by infertility is up there with cancer, loss of a loved one and major illness. Although fertility treatments (including IVF) can be exciting and restore optimism, they are extremely stressful. We encourage all of our patients to address their stressors and manage their stress to the best of their ability.
Acute and chronic stress can cause release of "fight anf flight" homrones such as cortisol and adrenalin - which can have negative effects on fertility and early pregnancy.
We have a holistic approach to our medical care, and encourage our patients to learn coping strategies, and to adopt lifestyle changes which are helpful to their health in general. Specifically, we encourage exercise activities such as yoga and medical therapies like acupuncture/acupressure.
Unlike men who continue to manufacture sperm until they die, women are born with a finite number of eggs. At birth, the ovaries contain millions of eggs. By the time of puberty there are approximately 200 - 300,000 eggs remaining in the ovaries for future ovulation. Although many eggs are recruited each month during a natural cycle, usually only one egg matures. However, it is a wasteful process, and many eggs are dying naturally every day.
In addition to the reduction in egg numbers as years advance, there is also a decrease in egg quality. This is why the chances of conception decline with advancing years. It is also the reason why there is an increased risk for genetic abnormalities with advancing age.
There are various ways of estimating ovarian reserve. These include blood tests and ultrasound. There is more information on this subjedt in the "InformationSheet" section.
You can contact our clinic through the contact e-mail address given on the website. If you live locally, the preferred consultation should be done in person. If you are located in Victoria and/or can make an incoming appointment work, please obtain a referral from your doctor to our clinic. Once we have this referral we will be in touch with an appointment date and time to come in an speak with one of our fertility specialist.
If you live out of town and would like to consider a treatment cycle at Victoria Fertility Centre, We will be happy to do a telephone consultation at a pre-arranged time. Please contact with reception with your details, and we can set this up.