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I often get asked by my patients whether or not stress impacts
on the chances of pregnancy. There are a number of studies that
do suggest there is an association between stress and pregnancy
outcome following the use of assisted reproductive technologies.
Researchers at the University of California, San Diego recently
found that patients who worry about certain aspects of their assisted
reproductive technology are likely to produce fewer eggs and have
a lesser chance of becoming pregnant than others who are more unconcerned.
In this well designed prospective study 150 women completed questionnaires
at their initial fertility clinic visit, and at the time of their
IVF procedure. The questionnaires, developed from a survey of the
scientific literature on stress and in vitro fertilization, focused
on concerns specific to IVF – side effects, surgery, anaesthesia,
pain recovery, finances, missing work and having a baby.
They found that women who are concerned about the medical aspects
of the procedure had 20% fewer eggs retrieved and 19% fewer eggs
fertilized, than women who were less inclined to worry about it.
Furthermore, women who are very concerned about missing work had
an astounding 30% fewer eggs fertilized. Those who were very concerned
about finances associated with the procedure, had a significantly
higher risk of not delivering a live infant. Furthermore, these
results were adjusted for different variables that could also play
a role in predicting the outcome of IVF – specifically, age,
race, smoking, type of infertility, number of previous attempts
to become pregnant, and number of children already born, were all
taken into account.
Further studies have shown that women/couples who have a good support
network in place overall have better outcomes. We at the Victoria
Fertility Centre acknowledge the effects that stress can have both
on the experience of the process of in vitro fertilization as well
as on the outcome. As much as possible, we encourage all patients
to visit with our reproductive psychologist to help identify any
potential stressors that need attention. The journey of fertility
is a very private affair, and this often will lead to our patients
feeling isolated and in many cases unsupported by friends and loved
ones through the entire process. With the help of our reproductive
psychologist, we encourage our patients to address the stress related
issues and modify them as much as possible. We also encourage any
form of activities such as yoga, acupuncture, exercise, massage
therapy, music, etc., which may be helpful.
Personally, I also believe that stress can have a considerable
effect on the immune system, which is so important for successful
embryo implantation and ongoing pregnancy. It still remains a medical
mystery as to how the immune system adapts to the foreign protein
and genetic material in an implanting embryo. The immune system
in the female is incredibly sophisticated. It is therefore not surprising
that it is more prone to malfunction – and this is reflected
in the fact that we see immune related disorders more commonly in
women than men, for example: systemic lupus erythematosis, rheumatoid
arthritis, thyroid dysfunction, and so on. It is common knowledge
to all of us that when we are over-stressed and fatigued we are
more prone to illnesses, typically, flu-like illnesses, cold sores,
herpes outbreaks and so on. This has to be all related to our immune
system. It therefore would be no surprise to extrapolate that stress
may adversely affect the female immune system when it comes to reproduction.
Healthy mind and healthy body are therefore imperative for optimizing
both the IVF experience and the outcome.
Dr. Janet Takefman, PhD., Counselor
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